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    Cagri+Semaglutide (CagriSema)

    Molecular Note: Fixed‑dose combination of two independent active ingredients without unified molecular formula
    Basic Property: CagriSema is a fixed‑ratio combination regimen of Cagrilintide and Semaglutide under phase‑3 evaluation for severe obesity.
    Structural Modification: Two separately modified acylated peptides retain their respective albumin‑binding half‑life advantages to match once‑weekly co‑injection scheduling.
    Dosage Forms: Combined subcutaneous injectable formulation for clinical trials; two separate raw powders for research compounding.
    Indications: Investigational indication for severe obesity unresponsive to single‑agent GLP‑1 treatment.
    Pharmacological Mechanism: Amylin‑pathway appetite suppression superimposes GLP‑1‑mediated metabolic regulation to cut total calorie intake more effectively than semaglutide monotherapy.
    Safety & Adverse Reactions: Gastrointestinal adverse events have slightly higher incidence than semaglutide alone; symptoms are manageable via slower do

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    Semaglutide
    Molecular Formula：C187H291N45O59；CAS：910463‑68‑2 Basic Property: Semaglutide is a long‑acting GLP‑1 receptor agonist developed by Novo Nordisk, classified as a modified peptide therapeutic supplied as research‑grade raw powder. Structural Modification: Three targeted modifications are adopted: position‑8 alanine replaced by α‑aminoisobutyric acid to resist DPP‑4 enzymatic degradation; position‑34 lysine substituted with arginine; position‑26 lysine conjugated with an 18‑carbon fatty diacid side chain via hydrophilic spacer for reversible albumin binding, extending serum half‑life to approximately 7 days. Dosage Forms: Two marketed dosage forms are available: once‑weekly subcutaneous injection (Ozempic, Wegovy) and once‑daily oral tablet (Rybelsus); raw powder is intended for laboratory research only. Indications: Licensed indications include glycemic control for adult type‑2 diabetes mellitus, chronic weight management for obese/overweight adults, and reduction of major adverse cardiov

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    Tirzepatide
    Molecular Formula：C225H348N48O68；CAS：2237882‑86‑7 Basic Property: Tirzepatide is a dual GIP/GLP‑1 receptor agonist developed by Eli Lilly, supplied as clinical injectable formulation and research‑grade lyophilized powder. Structural Modification: Altered amino‑acid sequence confers dual‑receptor affinity; C‑terminal fatty acid acylation achieves albumin binding and a 5‑day half‑life for once‑weekly dosing; structural mutation improves resistance to endogenous peptidase degradation. Dosage Forms: Once‑weekly subcutaneous prefilled injection pens (Mounjaro, Zepbound); bulk lyophilized powder exclusively for laboratory research. Indications: Approved for adult type‑2 diabetes treatment and chronic weight management for patients with BMI ≥30 or BMI≥27 accompanied by metabolic comorbidities. Pharmacological Mechanism: Co‑activates GIP and GLP‑1 pathways to improve insulin sensitivity, suppress appetite synergistically, reduce visceral adipose mass and ameliorate systemic insulin resistance.

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    Retatrutide (LY3437943)
    Molecular Formula：C237H362N52O71；CAS：2448063‑10‑7 Basic Property: Retatrutide is a triple‑target agonist (GLP‑1R/GIPR/GCGR) in phase‑3 clinical trials, available only as research‑grade raw peptide currently. Structural Modification: Optimized peptide backbone enables simultaneous binding to three metabolic receptors; fatty‑acid side‑chain acylation prolongs half‑life for once‑weekly subcutaneous administration; site‑directed mutation prevents rapid protease hydrolysis. Dosage Forms: Preclinical injectable solution and lyophilized bulk powder for research use only. Indications: Investigational indication for severe adult obesity and metabolic‑associated fatty liver disease. Pharmacological Mechanism: GLP‑1/GIP signals suppress appetite and optimize glucose homeostasis; glucagon receptor activation boosts brown fat thermogenesis and whole‑body fat oxidation to deliver superior weight‑loss efficacy. Safety & Adverse Reactions: Main adverse reactions are mild transient gastrointestinal sym

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    Mazdutide
    Molecular Formula：C221H344N48O67；CAS：2757233‑87‑1 Basic Property: Mazdutide is a domestic dual GLP‑1/GIP agonist independently developed by Innovent Biologics, now in late‑stage phase‑3 clinical trials in China. Structural Modification: Sequence optimization strengthens dual‑receptor binding affinity; fatty‑chain acylation achieves albumin anchoring and weekly administration frequency with improved peptidase stability. Dosage Forms: Clinical trial injectable formulation and research‑use lyophilized powder. Indications: Investigational indications include abdominal obesity, type‑2 diabetes and metabolic‑associated steatohepatitis. Pharmacological Mechanism: Dual‑pathway hormone regulation reduces waist circumference, inhibits hepatic lipid accumulation and improves peripheral insulin sensitivity alongside weight reduction. Safety & Adverse Reactions: Dose‑related nausea and vomiting are the primary adverse events; most symptoms resolve spontaneously after slow dose titration; no severe

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    Survodutide
    Molecular Formula：C210H324N46O64；CAS：2648339‑10‑8 Basic Property: Survodutide is a long‑acting GLP‑1/glucagon dual agonist in phase‑2 clinical research, distributed as research‑grade raw peptide powder. Structural Modification: Acylated side‑chain modification extends half‑life for weekly injection; engineered peptide structure balances the activation intensity of GLP‑1 and glucagon receptors. Dosage Forms: Preclinical subcutaneous injection solution and bulk lyophilized powder for laboratory research only. Indications: Investigational indication for obesity treatment with emphasis on long‑term weight rebound prevention. Pharmacological Mechanism: GLP‑1‑mediated appetite suppression pairs with glucagon‑triggered thermogenesis to sustain fat loss, preserve resting metabolic rate and reduce post‑withdrawal weight rebound. Safety & Adverse Reactions: Mild gastrointestinal reactions and temporary insomnia are reported in small cohorts; hepatic and renal function remain stable under short‑t

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    Liraglutide
    Molecular Formula：C172H268N44O47；CAS：204656‑20‑2 Basic Property: Liraglutide is a daily‑dose GLP‑1 analogue launched by Novo Nordisk, offered as injectable pharmaceutical finished product and research‑use raw peptide. Structural Modification: A palmitic acid fatty chain is covalently attached to the lysine residue of native GLP‑1, enabling reversible albumin binding to prolong half‑life to 13 hours and avoid rapid DPP‑4 cleavage. Dosage Forms: Subcutaneous daily injection for clinical application; lyophilized powder for preclinical laboratory testing. Indications: Approved for type‑2 diabetes glycemic regulation and moderate obesity weight management in adults. Pharmacological Mechanism: Promotes glucose‑triggered insulin secretion, inhibits fasting glucagon secretion, prolongs gastric emptying time and enhances post‑meal satiety to achieve steady weight loss. Safety & Adverse Reactions: Common mild adverse reactions are early‑stage nausea and abdominal distension which gradually relie

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    Dulaglutide
    Molecular Note: Fc‑fusion protein without small‑molecule molecular formula；CAS：923950‑08‑7 Basic Property: Dulaglutide is a recombinant fusion protein GLP‑1 agonist developed by Eli Lilly, designed for long‑term diabetic metabolic management. Structural Modification: Two DPP‑4‑resistant GLP‑1 analogues are covalently fused to human IgG4 Fc fragment; the Fc domain prolongs systemic half‑life to nearly 5 days via recycling through neonatal Fc receptor. Dosage Forms: Prefilled pen for once‑weekly subcutaneous injection; purified protein powder reserved for research experiments. Indications: Indicated for blood glucose control in adult type‑2 diabetic patients with cardiovascular comorbidities. Pharmacological Mechanism: Regulates islet hormone secretion in a glucose‑dependent pattern, slows intestinal nutrient absorption and lowers long‑term fasting blood glucose fluctuation, with mild auxiliary weight‑loss effect. Safety & Adverse Reactions: Mild gastrointestinal discomfort (diarrhea, dy

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    Cagrilintide (AM833)
    Molecular Formula：C215H347N61O63S3；CAS：1415456‑99‑3 Basic Property: Cagrilintide is a long‑acting acylated amylin analogue developed for obesity combination therapy, supplied as research‑use raw peptide. Structural Modification: Multiple amino‑acid substitutions enhance receptor affinity; fatty acid acylation prolongs circulation half‑life to support weekly dosing and resist endogenous peptidase degradation. Dosage Forms: Subcutaneous injection solution for combination clinical trials and lyophilized powder for preclinical research. Indications: Investigational indication for refractory obesity when combined with GLP‑1 agonists. Pharmacological Mechanism: Activates amylin and calcitonin receptors to slow gastric emptying, centrally reduce hedonic food craving and blunt postprandial blood glucose spikes. Safety & Adverse Reactions: Common adverse events are mild delayed gastric emptying symptoms such as early satiety; isolated mild injection‑site erythema occurs after subcutaneous deliv

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    Cagri+Tirzepatide
    Molecular Note: Compound regimen of Cagrilintide and Tirzepatide, two independent active peptides Basic Property: This three‑pathway compound combination integrates amylin, GIP and GLP‑1 agonism for preclinical and early‑phase obesity research. Structural Modification: Both acylated peptides maintain their original structural modifications for synchronized weekly administration. Dosage Forms: Mixed injectable solution for animal studies and two separate bulk powders for laboratory formulation preparation. Indications: Preclinical investigational use for morbid obesity with severe insulin resistance. Pharmacological Mechanism: Three complementary hormone pathways jointly inhibit hunger hormone secretion, shorten meal duration and lower daily energy intake drastically. Safety & Adverse Reactions: Preclinical data shows dose‑dependent gastrointestinal inhibition; long‑term multi‑organ safety is still under animal observation.

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