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    Mazdutide

    Molecular Formula：C221H344N48O67；CAS：2757233‑87‑1
    Basic Property: Mazdutide is a domestic dual GLP‑1/GIP agonist independently developed by Innovent Biologics, now in late‑stage phase‑3 clinical trials in China.
    Structural Modification: Sequence optimization strengthens dual‑receptor binding affinity; fatty‑chain acylation achieves albumin anchoring and weekly administration frequency with improved peptidase stability.
    Dosage Forms: Clinical trial injectable formulation and research‑use lyophilized powder.
    Indications: Investigational indications include abdominal obesity, type‑2 diabetes and metabolic‑associated steatohepatitis.
    Pharmacological Mechanism: Dual‑pathway hormone regulation reduces waist circumference, inhibits hepatic lipid accumulation and improves peripheral insulin sensitivity alongside weight reduction.
    Safety & Adverse Reactions: Dose‑related nausea and vomiting are the primary adverse events; most symptoms resolve spontaneously after slow dose titration; no severe 

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