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    Tirzepatide

    Molecular Formula：C225H348N48O68；CAS：2237882‑86‑7
    Basic Property: Tirzepatide is a dual GIP/GLP‑1 receptor agonist developed by Eli Lilly, supplied as clinical injectable formulation and research‑grade lyophilized powder.
    Structural Modification: Altered amino‑acid sequence confers dual‑receptor affinity; C‑terminal fatty acid acylation achieves albumin binding and a 5‑day half‑life for once‑weekly dosing; structural mutation improves resistance to endogenous peptidase degradation.
    Dosage Forms: Once‑weekly subcutaneous prefilled injection pens (Mounjaro, Zepbound); bulk lyophilized powder exclusively for laboratory research.
    Indications: Approved for adult type‑2 diabetes treatment and chronic weight management for patients with BMI ≥30 or BMI≥27 accompanied by metabolic comorbidities.
    Pharmacological Mechanism: Co‑activates GIP and GLP‑1 pathways to improve insulin sensitivity, suppress appetite synergistically, reduce visceral adipose mass and ameliorate systemic insulin resistance.

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