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    Retatrutide (LY3437943)

    Molecular Formula：C237H362N52O71；CAS：2448063‑10‑7
    Basic Property: Retatrutide is a triple‑target agonist (GLP‑1R/GIPR/GCGR) in phase‑3 clinical trials, available only as research‑grade raw peptide currently.
    Structural Modification: Optimized peptide backbone enables simultaneous binding to three metabolic receptors; fatty‑acid side‑chain acylation prolongs half‑life for once‑weekly subcutaneous administration; site‑directed mutation prevents rapid protease hydrolysis.
    Dosage Forms: Preclinical injectable solution and lyophilized bulk powder for research use only.
    Indications: Investigational indication for severe adult obesity and metabolic‑associated fatty liver disease.
    Pharmacological Mechanism: GLP‑1/GIP signals suppress appetite and optimize glucose homeostasis; glucagon receptor activation boosts brown fat thermogenesis and whole‑body fat oxidation to deliver superior weight‑loss efficacy.
    Safety & Adverse Reactions: Main adverse reactions are mild transient gastrointestinal sym

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