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    Cagrilintide (AM833)

    Molecular Formula：C215H347N61O63S3；CAS：1415456‑99‑3
    Basic Property: Cagrilintide is a long‑acting acylated amylin analogue developed for obesity combination therapy, supplied as research‑use raw peptide.
    Structural Modification: Multiple amino‑acid substitutions enhance receptor affinity; fatty acid acylation prolongs circulation half‑life to support weekly dosing and resist endogenous peptidase degradation.
    Dosage Forms: Subcutaneous injection solution for combination clinical trials and lyophilized powder for preclinical research.
    Indications: Investigational indication for refractory obesity when combined with GLP‑1 agonists.
    Pharmacological Mechanism: Activates amylin and calcitonin receptors to slow gastric emptying, centrally reduce hedonic food craving and blunt postprandial blood glucose spikes.
    Safety & Adverse Reactions: Common adverse events are mild delayed gastric emptying symptoms such as early satiety; isolated mild injection‑site erythema occurs after subcutaneous deliv

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